Eugene O Major Selected Research

Progressive Multifocal Leukoencephalopathy

1/2021	BK virus-specific T cells for immunotherapy of progressive multifocal leukoencephalopathy: an open-label, single-cohort pilot study.
1/2019	Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy.
1/2015	JC virus quasispecies analysis reveals a complex viral population underlying progressive multifocal leukoencephalopathy and supports viral dissemination via the hematogenous route.
5/2014	JC virus in CD34+ and CD19+ cells in patients with multiple sclerosis treated with natalizumab.
3/2012	JC virus promoter/enhancers contain TATA box-associated Spi-B-binding sites that support early viral gene expression in primary astrocytes.
1/2012	Changes in JC virus-specific T cell responses during natalizumab treatment and in natalizumab-associated progressive multifocal leukoencephalopathy.
1/2012	The link between VLA-4 and JC virus reactivation.
8/2011	Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring.
5/2011	CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes.
9/2010	Molecular regulation of JC virus tropism: insights into potential therapeutic targets for progressive multifocal leukoencephalopathy.

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Eugene O Major Research Topics

Disease

27	Infections 01/2022 - 12/2002
21	Multiple Sclerosis 01/2021 - 03/2006
18	Progressive Multifocal Leukoencephalopathy 01/2021 - 01/2003
6	Crohn Disease (Crohn's Disease) 07/2012 - 03/2006
5	HIV Infections (HIV Infection) 01/2020 - 04/2003
5	Acquired Immunodeficiency Syndrome (AIDS) 03/2012 - 07/2006
4	Inflammation (Inflammations) 01/2022 - 12/2006
4	Demyelinating Diseases (Demyelinating Disease) 01/2022 - 11/2009
4	Psoriasis (Pustulosis Palmaris et Plantaris) 05/2014 - 08/2009
4	Rheumatoid Arthritis 01/2010 - 03/2006
3	Hematologic Neoplasms (Hematological Malignancy) 01/2020 - 01/2010
3	Immune Reconstitution Inflammatory Syndrome 01/2017 - 09/2009
3	Viremia 06/2013 - 09/2005
2	Lymphopenia (Lymphocytopenia) 01/2017 - 08/2009
2	Brain Diseases (Brain Disorder) 01/2016 - 05/2011
2	Relapsing-Remitting Multiple Sclerosis 08/2011 - 05/2007
2	Drug-Related Side Effects and Adverse Reactions 08/2009 - 05/2009
2	Dementia (Dementias) 01/2006 - 07/2003
1	Body Weight (Weight, Body) 01/2019
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2018
1	Ataxia (Dyssynergia) 01/2017
1	Chronic Mucocutaneous Candidiasis 04/2016
1	Anhidrotic Ectodermal Dysplasia 1 01/2016
1	hypohidrotic Ectodermal dysplasia with immune deficiency 01/2016
1	Virus Diseases (Viral Diseases) 01/2015
1	Stroke (Strokes) 05/2014
1	Rare Diseases (Rare Disease) 09/2013
1	Neurocognitive Disorders (Clerambault Syndrome) 11/2012
1	Cytomegalovirus Infections (Inclusion Disease) 11/2010
1	Autoimmune Diseases (Autoimmune Disease) 09/2010
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 08/2009
1	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 05/2009
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 05/2009
1	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 05/2009
1	Pancytopenia 05/2009
1	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease) 05/2009
1	Opportunistic Infections (Opportunistic Infection) 05/2007

Drug/Important Bio-Agent (IBA)

19	Natalizumab (Tysabri)FDA Link 01/2020 - 03/2006
10	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 05/2004
5	Monoclonal AntibodiesIBA 07/2012 - 08/2009
4	efalizumab (Raptiva)FDA Link 05/2014 - 08/2009
3	AntibodiesIBA 05/2014 - 05/2003
3	Viral ProteinsIBA 11/2011 - 05/2003
3	Rituximab (Mabthera)FDA Link 01/2010 - 05/2009
2	Pharmaceutical PreparationsIBA 01/2018 - 12/2006
2	Messenger RNA (mRNA)IBA 11/2011 - 08/2005
2	Proteins (Proteins, Gene)FDA Link 03/2009 - 07/2003
2	Viral DNAIBA 06/2007 - 08/2005
2	NestinIBA 06/2007 - 07/2004
1	Viral AntigensIBA 01/2022
1	belnacasanIBA 01/2021
1	CuprizoneIBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2020
1	Chloroquine (Aralen)FDA LinkGeneric 01/2020
1	Peptides (Polypeptides)IBA 01/2020
1	pembrolizumabIBA 01/2019
1	InflammasomesIBA 01/2018
1	Mirtazapine (Rexer)FDA LinkGeneric 01/2017
1	Intravenous Immunoglobulins (IVIG)FDA Link 01/2017
1	SteroidsIBA 01/2017
1	Interleukin-7 (Interleukin 7)IBA 01/2017
1	Mefloquine (Lariam)FDA LinkGeneric 01/2017
1	Methylprednisolone FDA LinkGeneric 01/2017
1	STAT1 Transcription FactorIBA 04/2016
1	I-kappa B KinaseIBA 01/2016
1	EnzymesIBA 05/2014
1	FumaratesIBA 05/2014
1	ImmunosorbentsIBA 05/2014
1	CateninsIBA 11/2012
1	Carrier Proteins (Binding Protein)IBA 11/2011
1	Antiviral Agents (Antivirals)IBA 05/2011
1	Bromodeoxyuridine (BrdU)IBA 05/2011
1	EstersIBA 11/2010
1	brincidofovirIBA 11/2010
1	LipidsIBA 11/2010
1	Transcription Factors (Transcription Factor)IBA 09/2010
1	Integrin alpha4beta1 (VLA-4)IBA 01/2010
1	Lymphocyte Function-Associated Antigen-1 (LFA-1)IBA 01/2010
1	Cell Adhesion MoleculesIBA 01/2010
1	integrin alpha4beta7IBA 11/2009
1	Protein Isoforms (Isoforms)IBA 07/2009
1	Azathioprine (Imuran)FDA LinkGeneric 05/2009
1	Adrenal Cortex Hormones (Corticosteroids)IBA 05/2009
1	Immunoglobulin G (IgG)IBA 10/2008
1	Transforming Growth Factor beta1 (TGF beta 1)IBA 06/2007
1	N-nitrosoiminodiacetic acidIBA 12/2006
1	NeurotoxinsIBA 07/2006
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2006
1	Biological ProductsIBA 01/2006

Therapy/Procedure

13	Therapeutics 01/2021 - 01/2003
3	Immunotherapy 01/2021 - 11/2004
2	Biological Therapy 01/2012 - 01/2010
2	Plasma Exchange 09/2010 - 09/2009
2	Aftercare (After-Treatment) 08/2009 - 05/2009
2	Kidney Transplantation 10/2008 - 09/2005
1	Immunomodulation 01/2010
1	Drug Therapy (Chemotherapy) 08/2009
1	Highly Active Antiretroviral Therapy (HAART) 06/2007
1	Lasers (Laser) 06/2007